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IJAMSB Abstract

Aloe Vera Heals Gactric Ulcer in 7 Days Than Omeprazole and Cimetidine: Prostaglandin?

Jimmy E.O.1*, UmohI.U.2, and Usun V.J.1

1Department of Human Physiology, Faculty of Basic Medical Sciences, University of Uyo Akwa Ibom State Nigeria.

2Department of Human Anatomy, Faculty of Basic Medical Sciences, University of Uyo Akwa Ibom State Nigeria.

*Corresponding Author’s Contact Detail: Email address ✉: medstedrecheo@yahoo.com

Accepted October 27, 2020

Peptic ulcer disease is becoming a very common disease as it is associated with life style e.g eating habit more than infection, by bacteria, H.pylori. There are various types treatments for the disease which are not very potent for the eradication of the disease. A comparative study was therefore carried out with Aloe vera, cimetidine and omeprazole to arrive at the most potent treatment drug. A total of thirty (30) male and female rats were used for the study. The Aloe vera extract with LD50 of 1870.83mg/kg was administered in three dosages; low, medial and high, 187.08mg/kg, 374.42 mg/kg and 561.25mg/kg respectively in groups III – IV while cimetidine and omeprazole in groups V and VI respectively for the period of 28 days. Gastric Hcl increased significantly P<0.1 in group III as compared to the control but was not significant p>0.01 in group II, IV and VI. Aloe vera showed a more potent healing than omeprazole and Cimetidine as there was no traces of ulceration observed in the stomach of the rats as early as 7 days of the observation treatment. However, the acid output in the aloe vera treated groups were not significantly reduced p>0.01 as compared to Cimetidine and omeprazole groups. But the ulceration was significantly eliminated than in the cimetidine and omeprazole treated groups. It is concluded that Aloe vera probably acts through prostaglandin increase in its ingredient for the healing of ulcer.

Keywords: Aloe Vera, Cimetidine, omeprazole, Hcl, gastric ulcer.

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