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IJAMSB Abstract

Biochemical Indices of Combined Measure of Serum Uric Acid and Beta Human Chorionic Gonadotropin (β hCG) Versus Serum Uric Acid alone as Prognostic Indicators of Pregnancy Outcome of Preeclampsia

Allagoa D.O.1, Aigere E.O.S.1, Obagah L.1, Kotingo E.L.1*, Jeremiah I.1, Kasia B.E.2, and Oriji P.C.1

1Department of Obstetrics and Gynaecology, Federal Medical Centre, Yenagoa, Bayelsa State, Nigeria.

2Department of Chemical Pathology, Niger Delta University Teaching Hospital, Okolobiri, Bayelsa State, Nigeria.

*Corresponding Author’s Contact Detail: Email address ✉: kotingolucky2009@yahoo.com

Accepted October 26, 2020

Possible biochemical indices of preeclampsia have been sought for many years. The aim of this study is to evaluate the accuracy of combined measure of maternal serum uric acid level and quantitative serum beta hCG versus serum uric acid level alone as prognostic indicators of pregnancy outcome among preeclamptic patients at the Federal Medical Centre, Yenagoa. This is a hospital based prospective case control study by systematic sampling selection. The two groups comprised of 100 consecutive patients each, one with pre-eclampsia (study group) and the other without pre-eclampsia (control) admitted for management into the antenatal ward and labour ward over the seven-month period of the study. The values of their serum uric acid and beta hCG levels were evaluated on admission and followed up. Data entry and statistical analysis were done using statistical package for social science (windows version 22.0. SPSS Inc; Chicago, USA). Level of significance was set at P < 0.05. The mean serum uric acid level was higher amongst participants with preeclampsia (405.6 ± 99.5 µmol/L) than in those without preeclampsia (232.7 ± 26.3 µmol/L) and this difference was statistically significant (p= 0.001). The prognostic accuracy in predicting pregnancy outcomes were: HELLP syndrome (0.25, 0.44), Eclampsia (0.13, 0.50), Acute Renal Failure (0.27, 0.44), IUGR (0.31, 0.43), IUFD (0.27, 0.38) and Birth Asphyxia (0.35, 0.49) respectively for serum uric acid alone and combined measure of serum uric acid and serum β hCG. Serum uric acid levels were found to be useful prognostic indicators for feto-maternal outcome in women with preeclampsia. However, combined measure of serum uric acid and serum β hCG level in prognosticating pregnancy outcome in preeclamptic women was shown to have a better accuracy than either serum uric acid.

Keywords: Preeclampsia, pregnancy outcome, prognostic indicators and accuracy, uric acid.

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